Written by Brian K. Vaughan and with art by Pia Guerra, this is the saga of Yorick Brown-the only human survivor of a planet-wide plague that instantly kills every mammal possessing a Y chromosome. Accompanied by a mysterious government agent, a brilliant young geneticist and his pet monkey, Ampersand, Yorick travels the world in search of his lost love and the answer to why he's the last man on earth. Collecting issues #1-5.