Eleanore of Avignon is the story of a woman who is unwilling to bend to the limitations her society places upon her when she becomes the unlikely apprentice to the pope’s physician at the most challenging and dangerous moment in medieval European history. Provence, 1347. Eleanore (Elea) Blanchet is a midwife and budding herbalist with remarkable skills. But as she knows all too well from her late mother’s fate, she must be careful to stay within her station. So, she quietly accepts her role tending to the pregnant women in her home city of Avignon; spending time with her father and beloved twin sister, Margot; and escaping to the surrounding woods to forage for herbs when she can. At the very least, she is determined to preserve the little freedom she does have by staying unwed—unlike Margot, who is about to marry a man with painful connections to their mother’s death. Then, in a chance encounter, Elea meets Guy de Chauliac, “Guigo,” the enigmatic personal physician to the powerful Pope Clement, who, against all odds, agrees to take her on as his apprentice. Under his tutelage, a whole new world opens to Elea—a world of status, wealth, and fascinating medical cases—but just as she starts to settle into her new position, the much-feared plague hits Europe, making Elea and Guigo's work more urgent than ever. And as if that weren’t enough, the disgraced Queen Joanna of Naples arrives in Avignon to stand trial for her husband’s murder—and she is pregnant and in need of a midwife, a role only Elea can fill. As the Black Death spreads like wildfire, leaving half the city dead in its wake—and as the queen's childbirth approaches—Elea finds herself battling what seems to be an unwinnable war. All the while, the people of Avignon are becoming more and more desperate for a scapegoat, and a group of religious heretics launch a witch hunt, one that could cost her everything.